Construction and Application of a Large-scale DNA Sequence Analysis System Based on PC/Linux
- VernacularTitle:基于PC/Linux的核酸序列分析系统的构建及其应用
- Author:
Chenggang ZHANG
;
Shuguang OUYANG
;
Shaowe ZHANG
;
Xianghu QU
;
Yongtao YU
;
Gangqiao ZHOU
;
Songfeng WU
;
Fuchu HE
- Publication Type:Journal Article
- Keywords:
personal computer;
Linux operating system;
Phred/Phrap/Consed software;
Blast software;
bioinformatics;
large-scale DNA sequencing
- From:
Progress in Biochemistry and Biophysics
2001;28(2):263-266
- CountryChina
- Language:Chinese
-
Abstract:
More and more DNA sequences have been obtained since the start-up of human genome project. Powerful system is badly needed for data mining on these DNA sequences. Based on a personal computer and Linux operating system, the Phred/Phrap/Consed software and Blast software were used to construct a platform for batch analysis of the sequences, including identifying raw DNA sequence from chromatogram file, vector sequence removing, contig analysis (sequence assembly), repeat sequence identifying and sequence similarity analysis. Result demonstrated that this robust platform could accelerate data analysis for large-scale DNA sequencing.
