Neuromuscular and hemodynamic effects of mivacurium and succinylcholine in adult patients during nitrous oxide-propofol-fentanyl anesthesia.
10.3346/jkms.1993.8.5.374
- Author:
Kyung Ho HWANG
1
;
Sun Chong KIM
;
Sung Yell KIM
;
Naoyuki UEDA
;
Takesuke MUTEKI
Author Information
1. Department of Anesthesiology, School of Medicine, Soonchunhyang University, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Neuromuscular Relaxants;
mivacurium;
succinylcholine;
Henodynamic Effects
- MeSH:
Adult;
Anesthesia;
Female;
Fentanyl/administration & dosage;
Hemodynamics/*drug effects;
Humans;
Isoquinolines/*pharmacology;
Male;
Neuromuscular Junction/*drug effects;
Neuromuscular Nondepolarizing Agents/*pharmacology;
Nitrous Oxide/administration & dosage;
Propofol/administration & dosage;
Succinylcholine/*pharmacology
- From:Journal of Korean Medical Science
1993;8(5):374-379
- CountryRepublic of Korea
- Language:English
-
Abstract:
The neuromuscular and hem+odynamic effects of mivacurium 0.15 mg/kg and succinylcholine 1 mg/kg were compared in 26 adult patients (ASA I and II) during nitrous oxide-oxygen-propofol-fentanyl anesthesia. Neuromuscular block was monitored by recording the compound electromyogram of the hypothenar muscle resulting from supramaximal train-of-four stimuli applied to the ulnar nerve. Time to onset of over 95% block and duration to 25% recovery of control twitch after injection of mivacurium were significantly longer than for succinylcholine (201 +/- 37.6 vs 54 +/- 5.2 sec and 13.0 +/- 2.2 vs 8.4 +/- 2.1 min; mean +/- SD). Onset of mivacurium with priming technique was shortened (125 +/- 20.7 sec), but was also slower than that of succinylcholine. Although the recovery index during spontaneous recovery was significantly longer for mivacurium than for succinylcholine (6.9 +/- 1.3 vs 5.1 +/- 0.9 min), antagonism with neostigmine at 25% recovery of twitch height sufficiently facilitated the recovery index of mivacurium (4.5 +/- 1.0 min) to a level similar to that of succinylcholine with no statistical difference. The hemodynamic effects of mivacurium were few as compared to those of succinylcholine. In conclusion, mivacurium is considered to have additional advantages for short procedures when succinylcholine is undesirable.
