Advances in the Study of the MCT Gene Family
- VernacularTitle:单羧酸转运泵基因家族研究进展
- Author:
Guizhi ZHANG
;
Guijun HUANG
;
Xianjian GUO
- Publication Type:Journal Article
- Keywords:
monocarboxylate transporter;
lactate;
cancer
- From:
Progress in Biochemistry and Biophysics
2001;28(2):172-175
- CountryChina
- Language:Chinese
-
Abstract:
monocarboxylate transporter (MCT) are vital transmembran e transporters involved in multiple cellular functions including the regulation of intracellul ar pH and lactate transport. At least eight isoforms of MCT have been cloned and characterized to date, they constitute a new gene family of mammal transporters . These isoforms have the differences in substrate and inhibitor specificities a nd tissue distribution. Thus it may provide a new way of diagonosis and treating for dieases such as cancer by investigating on the structure and function and r egulational mechanism of MCT.
