Mitochondria, Reactive Oxygen Species and Apoptosis
- VernacularTitle:线粒体，活性氧和细胞凋亡
- Author:
Yungang ZHAO
;
Jianxing XU
- Publication Type:Journal Article
- Keywords:
mitochondria;
reactive oxygen species;
apoptosis;
elect ron leak;
cytochrome c
- From:
Progress in Biochemistry and Biophysics
2001;28(2):168-171
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria are involved not only in energy metabolism but also in free radical metabolism. Superoxide anion can be generated through a way of electron leak of respiratory chain and the reactive oxygen species (ROS ) can be formed in the further reactions of O2* in mitochondria. The role of mitochondria in anti-oxidant functions and cell apoptosis is discu ssed in terms of electron leak of respiratory chain, uncoupling of oxidative pho sphorelation, mitochondrial pore, Box- or/and PTP-mediated release of cytochro me c from mitochondria and so on. The signaling act of ROS is emphasized in the regulation of cell apoptosis.
