Advances in the Anandamide
- VernacularTitle:花生四烯乙醇胺的研究进展
- Author:
Weimin LIU
;
Enkui DUAN
- Publication Type:Journal Article
- Keywords:
anandamide;
cannabinoid receptors;
signal transduction
- From:
Progress in Biochemistry and Biophysics
2001;28(2):152-155
- CountryChina
- Language:Chinese
-
Abstract:
Anandamide (N-arachidonoylethanolamide), an arachidonic acid derivative, is an endogenous ligand for cannabinoid receptors, which are m embers of the G protein (Gi)-coupled receptors family. Ananamide is mainly foun d in central nervous system, immune system and uterus etc and mimics most of the effects of (－)Δ9-tetrahydrocannabinoid ［(－)Δ9-THC］, a psyco active derivative of marijuana. Fatty-acid amide hydrolase (FAAH), which is inv olved in hydrolyzing anandamide to arachidonic acid and ethanolamide, may quickl y regulate level of anandamide in vivo.
