PH Domain and Cells Sense of Direction
- VernacularTitle:PH结构域与细胞方向感觉
- Author:
Shiying LI
;
Xiaohui LI
- Publication Type:Journal Article
- Keywords:
PH domain;
cells sense direction;
cytosolic regulator of adenylyl cyclase protein(CRAC)
- From:
Progress in Biochemistry and Biophysics
2001;28(2):145-147
- CountryChina
- Language:Chinese
-
Abstract:
The cells sense direction is closely related with the proteins that contain PH (pleckstrin homology) domain. PH domain has been found in about 60 proteins, many of which could activate the sequent events of signal transduction via combining with the related binding sites on the surface of chematactic cel ls. The characteristics of this combining are: a.rapid and transient; b.It is only related to the concentration gradient of surroundings outside cells, whi ch is the base of spatial model; c.The distribution of the binding sites on th e cell membrane changes when the researchers altered the position of the chemoat tractant. This is the base of temporal model. To deeply investigate the effects of all kinds of proteins which contain PH domain on cells sense of direction will greatly promote the research of this field, and hence, has great theoretica l significance.
