Expression of MMP-2 and MMP-9 in 53 Cases of Salivary Adenoid Cystic Carcinoma and Its Relationship with Invasion and Metastasis
- VernacularTitle:53例涎腺腺样囊性癌MMP-2和MMP-9表达与神经浸润和淋巴结转移的关系
- Author:
Feng TANG
;
Hong WANG
;
Weizhi ZHAO
;
Wei LI
;
Qiong LI
;
Li ZHUANG
- Publication Type:Journal Article
- From:
Fudan University Journal of Medical Sciences
2001;28(2):121-123
- CountryChina
- Language:Chinese
-
Abstract:
PurposeTo study the patterns of the expression of MMP-2 and MMP-9 in human salivary adenoid cystic carcinoma and evaluate the relationship between the expression and nerve invasion and lymph node metastasis. MethodsThe immunohistochemical location of MMP-2 and MMP-9 was evaluated by using Envision immunoperoxidase technique. Studies were performed in 53 surgical excised specimens. The immunohistochemical staining results were densitometrically semiquantitatived. ResultsThe expressions of MMP-2 and MMP-9 in salivary adenoid cystic carcinoma were 67.92 % and 79.25 % respectively. The MMP-2 and MMP-9 levels in salivary adenoid cystic carcinoma with nerve invasion were much higher than those without invasion(P＜ 0.05, P＜ 0.05 respectively), and the percentage of lymph node metastasis rose with the change of MMP-2 and MMP-9 (P ＜ 0.05, P ＜ 0.05 respectively). ConclusionsThe results indicate that the rise of MMP-2 and MMP-9 correlate with the nerve invasion and lymph node metastasis.
