Expressions of p53 and nm23 proteins in oral squamous cell carcinoma
- VernacularTitle:口腔粘膜鳞癌组织中P53和nm23蛋白的表达分析
- Author:
Minghua GE
;
Gu ZHANG
;
Kejing WANG
- Publication Type:Journal Article
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2001;8(2):107-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions of P53and nm23 proteins in cancer tissue of patients with oral squamous cell carcinoma.Methods:There were 57 males and 43 females,ranging in age from 35 to 75 years old.The clinical stages were T1 10,T2 29,T3 56 and T4 5;pathologic classifications were high differentiation in 74,medial and low differentiation in 26;lymph node metastasis in 56,no metastasis in 44.The expressions of P53 and nm23 proteins were detected by immunohistochemical technique.Results:The expressions rates of P53and nm23 proteins were 58.0%(58/100) and 40.0%(40/100) respectively (P＜0.05)in cancer tissue of patients with oral squamous cell carcinoma.The expressions rates of P53and nm23 were 71.5%(40/56)and 28.6%(16/56)in group of patients with node lymph node metastasis;40.9%(18/44)and 54.5%(24/44) in group of patients with negative metastasis respectively.Conclusion:Lymph node metastasis might be correlated with high level expression of P53 protein and low level expression of nm23 protein in patients of oral squamous cell carcinoma.
