Molecular biological markers on diagnosis of early gastric cancer
- VernacularTitle:胃癌早期诊断的相关分子生物学指标
- Author:
Jian CAI
;
Kun CHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Disease Control & Prevention
2001;5(2):139-141
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer(GC) is deeply threatening the health of our people, the mortality rate of GC is the second death cause of carcinoma i n our country. Since the lack of special clinical symptom at the early state of GC, detecting GC at the molecular biological level is expected to diagnose early gastric cancer. This article discusses some markers such as PCNA, p53, telomera se, ras protein and so on to assess the possibility of diagnosing the early gas tric cancer with these molecular biological markers. According to analyzing rela ted papers published, PCNA and p53 were found to be the molecular biological mar kers which should be firstly taken into account in diagnosing gastric cancer. Bo th of them can be easily detected by using immunohistochemical method. Telomeras e is also a good marker, but because of its difficult technology and high cost, it is not so practicable as the former two as the diagnostic marker of early gas tric cancer. Besides, ras potein can also be taken into account as the early det ecting auxiliary marker for GC.
