Effect of probucol on adhesion of human monocytic line THP-1 induced by oxidiz ed low density lipoprotein
- VernacularTitle:普罗布考对oxLDL诱导的人单核细胞株THP-1粘附功能的影响
- Author:
Chun LIANG
;
Zonggui WU
;
Zuo HUANG
;
Renqian ZHONG
;
Lingzhen ZHANG
;
Li LI
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2001;22(2):148-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the eff ect of probucol on adhesion of human monocytic line THP-1 induced by oxidized low density lipoprotein (oxLDL). Methods: THP-1 cells were induced by oxLDL in vitro. The CD11b, CD54 expressions and adhesion to human umbilic al vein endothelial cells (HUVEC) were measured after treatment with probucol at different concentrations by flow cytometry and β-nitrophenyl N-acetyl-β-D -glucosminide test. Results: Probucol inhibited the adhesion of oxLDL-induced THP-1 cells to HUVEC and down regulated the expression of CD11b in a dose dependent manner (P<0.01), but there was no inhibition on exp ression of CD54. Conclusion: Probucol can inhibit adhesion and a ggregation of monocyte-macrophages to endothelium in circulation, and may have anti-inflammatory action.
