Changes of lung microvascular permeability in blunt chest trauma, endotoxemia and their combined injury in rats
- VernacularTitle:胸部撞击伤、内毒素血症及其复合损伤对大鼠肺血管通透性的影响
- Author:
Kelong LIAO
;
Peifang ZHU
;
Zhengguo WANG
;
Jiakai LU
;
Lei LI
;
Zhiyong YIN
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
2001;23(2):199-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of the microvascular permeability after blunt chest trauma (BCT), endotoxemia and their combined injury in rats. Methods After the establishment of the rat models of BCT, endotoxemia and their combined injury in the right lungs, the fluorescein sodium (FINa) content was measured with flurospectrophotometer in lungs 0.5, 1, 4 and 8 h after injury. Results There was an early obvious increase of the microvascular permeability in the impact lateral (peak at half an hour after injury), and a delayed increase in the contralateral lung (peak at the 8th h) in the BCT group. The FINa content was higher in endotoxemia group than in the BCT group(P<0.05), and lower than that in the combined injury group(P<0.05) in the contralateral lung. Conclusion Results indicate that there were different pathophysiologic processes among the 3 kinds of injury and the FINa content is a useful index to manifest the changes of microvascular permeability in tissues.
