Experimental study of Verapamil in kidney graft preservation
- VernacularTitle:异搏定在离体肾保存中应用的实验研究
- Author:
Mingqi FAN
;
Yinfu ZHANG
;
Huageng MO
;
Chibing HUANG
;
Zhilin YAN
;
Pingxian WANG
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
2001;23(2):215-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of calcium antagonist Verapamil (VP) on kidney preservation in HCA solution. Methods After kidneys were isolated from rabbits, they were perfused and stored in HCA solution or in HCA solution with VP pre-supplement at 4℃ for 24 h respectively. The contents of mitochondrial calcium in renal cells and ATP in renal tissues were measured in every group. Results The contents of mitochondrial calcium was remarkably higher and ATP significantly lower in the kidneys in HCA solution at 4℃ for 24 h than those just after resection. But these could be inhibited in those storing in the HCA solution with VP pre-supplement. Conclusion Calcium antagonist VP can protect kidney function during HCA solution preservation by inhibiting calcium intaking into mitochondrium.
