Study of Experimental Parkinsonian Animal by Using High Performance Liquid Chromatography with Polymer-Overoxidized Polypyrrole Film Chemically Modified Electrode
- VernacularTitle:过氧化聚吡咯膜修饰电极色谱电化学用于帕金森试验动物的研究
- Author:
Wen ZHANG
;
Qun XU
;
Xuni CAO
;
Meichuan LIU
;
Litong JIN
- Publication Type:Journal Article
- From:
Chinese Journal of Analytical Chemistry
2001;29(2):133-137
- CountryChina
- Language:Chinese
-
Abstract:
A novel polymer- overoxidized polypyrrole film chemically modified electrode (CME) as the liquid chromatography-electrochemical detector (LC-ECD) was fabricated and applicated, which could be used to determine the monoamine neurotransmitters. The experimental model of parkinsonian animal was established by using medicine. Microdialysis sampling coupled with LC-ECD was used to monitor the monoamine neurotransmitters and their metabolites in experimental animal brain in vivo under different situations. The mechanism of experimental animal's Parkinsonian disease was studied elementarily. An accurate and reliable analysis method was supplied for filting the new and the more effective medicine to cure parkinsonian disease.
