Study on the Pharmacokinetics of Psoralen and Isopsoralen by Fluorometry

VernacularTitle:用荧光法研究补骨脂素与异补骨脂素的药代动力学
Publication Type:Journal Article
From: Chinese Journal of Analytical Chemistry 2001;29(2):146-149
CountryChina
Language:Chinese
Abstract: Psoralen and isopsoralen are the main effective content in fructus psoraleae. In order to study the relation between pharmacodynamice andpharmacokinetics, micellar fluorometry was used to monitor berberine blood-drug concentration in rabbit for 24 hours, and a series of pharmacodinetics parameters were obtained. Those are Ka =3.225h-1, t1/2(α) = 0.1849h, t1/2 (β) = 10.7065h, T = 0.8200h,AUC = 21.6104 × 10-6 mg· h/L for psoralen,and Ka = 4.4329h- 1, t1/2 (Ka) = 0.156h, t1/2( Ka ) = 2. 1777h, T = 1.0955h, AUC = 7. 2418 × 10-6g· h/mL for isopsoralen.