Flow Injection Spectrophotometric Determination of Metoclopramide
- VernacularTitle:甲氧氯普胺的流动注射光度分析
- Author:
Jing FAN
;
Yahong CHEN
;
Cunling YE
;
Suling FENG
- Publication Type:Journal Article
- From:
Chinese Journal of Analytical Chemistry
2001;29(2):216-218
- CountryChina
- Language:Chinese
-
Abstract:
A rapid and sensitive flow-injection spectrophotometric method was proposed for the determination of metoclopramide. This method was based on the diazotisation of metoclopramide with sodium nitrite in acidic medium and coupling with α-naphthylamine. The optimal experimental condition was obtained by using the simplex optimization method. The linear range was 0.0 ～ 30 mg/L, and the sample throughput was 160 samples h-1. The relative standard deviation of eleven replicate measurements was less than 0.6%. The method was used to determine metoclopramide in tablets and injections. The results were statistically compared with those obtained by pharmacopoeia method.
