Determination of Content and Dissolution of Levothyroxine Sodium Tablet by RP-HPLC
- VernacularTitle:RP-HPLC法检测左旋甲状腺素钠片剂含量及溶出度
- Author:
Jiexiong WU
;
Bin REN
;
Lei TANG
- Publication Type:Journal Article
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2001;22(3):238-240
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To determine the content and dissolution of two imported levothyroxine sodium tablets.【Method】The content of levothyroxine sodium was assayed on a Hypersil BDS C18 column with a mobile phase consisting of methanol-0.85% phosphoric acid (60∶40) at a flow rate of 1.5 mL/min and detected at 225 nm.The study on dissolution was conducted according to the method Ⅱ of dissolution apparatus in USP(23).【Results】The average content of two formulations was 107.74% and 99.72%,respectively.The value of T50,Td and m of two tablets differed significantly (P<0.01).【Conclusion】There was a significant dissolution difference between two levothyroxine sodium tablets.
