A study of mossy fiber sprouting in hippocampus of genetically epilepsy-prone rats——P77PMC
- VernacularTitle:遗传性癫疒间易感大鼠P77PMC海马苔藓状纤维发芽的研究
- Author:
Shigang ZHAO
;
Qiang LUO
;
Xiru WU
- Publication Type:Journal Article
- From:
Journal of Peking University(Health Sciences)
2001;33(2):101-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective： To investigate pathophysiologic mechanism about initiation and propagation of epilepsy in a genetically epilepsy-prone rat (GEPR) model. Methods： The hippocampal MF sprouting of P77PMC rats was examined at different stages in the course of recurrent seizures using Timm method of sulfide silver staining. Results：The three groups of P77PMC rats which experienced 30 and less than 30 times of audiogenic seizure ( AGS ) and the Wistar control group did not display MF sprouting in dentate gyrus, however, the group of P77PMC rats which experienced 50 times of AGS was found hippocampal MF sprouting into the inner molecular layer of dentate gyrus. Conclusion：Our findings suggest that hippocampal MF sprouting presented not only in limbic seizure, but also in AGS, the seizure initiated in brainstem but rapidly generalized; in AGS-prone rats, recurrent AGSs can induce MF synaptic reorganization in hippocampus.
