Antihypertensive effect of L-amlodipine in SHRs and anaesthe tic dogs
- VernacularTitle:左旋氨氯地平对自发性高血压大鼠血压和心率以及麻醉犬血压的影响
- Author:
Chengyu LU
;
Hong LI
;
Xuefeng SUN
;
Shijie YANG
- Publication Type:Journal Article
- From:
Journal of Jilin University(Medicine Edition)
2001;27(2):132-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the antihypertensive effect of L-amloipine with that of a mlodipine.Methods:Blood pressure and heart rate of SHRs were measured with blood press ure meter of rat (SBP-1) by administrating L-amlodipine and amlopdipine through mo uth.Hemodynamic parameter of anaesthetic dogs was determined by administrating drugs through duodenum with Polygraph System (RM6000).Results:L-amlodipine could slowly reduce the blood pressure and heart rates of clearing SHRs,it could also reduce the blood pressure of normal anaesthetic dogs and the action of L-amlodipine was similar to that of amlodipine.Conclusion:L-amlodipine as a new antihypertensive drug can significantly re duce blood pressure.
