Effect of TGF-β on collagen degradation of rabbit keratocytes
- VernacularTitle:转化生长因子β1对兔角膜基质细胞胶原降解代谢的影响
- Author:
Yun LI
;
Bingjie ZHANG
;
Zhengyu YIN
;
Buoming LIU
;
Jilong HAO
;
Hui JIA
;
Jiyu ZHANG
- Publication Type:Journal Article
- From:
Journal of Jilin University(Medicine Edition)
2001;27(2):153-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of TGF-β1 on collagen degradation of rabbit keratocytes.Methods:The activity of collagen degradation of keratocytes with three-dime nsional culture in collagen gel was determined with spectrophotometer.Results:TGF-β inhibited collagen degradation of keratocytes in dose-dependent manner.Conclusion:The present result suggests that TGF-β1 has the inhibitory effect on collagen degradation of keratocytes and may help in the treatment of corneal ulceration.
