Relation between angiogenesis and cell proliferative poten tial in human meningiomas

VernacularTitle:人脑膜瘤血管生成和细胞增殖能力的关系
Author: Yunqian LI ; Yunpeng JIANG ; Qi LUO ; Cai LI
Publication Type:Journal Article
From: Journal of Jilin University(Medicine Edition) 2001;27(2):158-160
CountryChina
Language:Chinese
Abstract: Objective:To study the relation of angiogenesis with cell proliferative postenti al in human meningiomas.Methods:Expression of factor Ⅷ-related antigen (FⅧRAg) and proliferating cell nuclear antigen (PCNA) was detected by immunohistochemistry in 38 specimens of human meningiomas,including 14 benign,12 atypical and 12 anaplastic (malignant) menningiomas and the correlation of microvessel density (MVD) with PCNA labellin g index (PCNA LI) was analyzed.Results:There was no significant difference in MVD between benign and atypical m eningiomas (P>0.05).MVD was higher in analplastic meningiomas than in both benign and atypical tumors (P<0.01).PCNA LI was markedly higher in anaplast ic meningiomas than in benign and atypical tumors (P<0.01). A significant c orrelation between MVD and PCNA LI was not detected in benign tumors;whereas,MVD positively correlated with PCNA LI in both atypical (r=0.518,P<0.01) and a naplastic (r=0.358,P<0.01) meningiomas. Conclusion:Angiogenesis is linked to cell proliferative potential in both atypic al and anaplastic meningiomas.