Effects of thymopeptides on cell immune function of patients with malignant tumor under radiotherapy
- VernacularTitle:胸腺肽对恶性肿瘤放疗病人细胞免疫功能的影响
- Author:
Zhe LU
;
Yaqin QU
;
Shouliang GONG
;
Shibo FU
;
Xiaojing JIA
;
Zhenfeng WU
;
Linqing HUANG
;
Ling LI
- Publication Type:Journal Article
- From:
Journal of Jilin University(Medicine Edition)
2001;27(2):168-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study effects of large dose thymopeptides on T cell subpopulations of patients with malignant tumor under radiotherapy.Methods:Fifty one patients with malignant tumor under radiotherapy were divided into 2 groups with 100 mg and 200 mg thymopeptides respectively.The patients we re given thymopeptides,100 mg/d or 200 mg/d,iv, for 10 days.The positive percent ages of CD4,CD8,CD25 and CD56 in T cells of peripheral blood before and after thymopeptide treatment were determined by flow cytometry.Results:The positive percentages of CD4 and CD25 in T cells of peripheral bl ood after 100 mg/d thymopeptide treatment were significantly higher than those befor e thymopeptide treatment (P<0.05),while those of CD4，CD8，CD25 and CD56 in T cells of peripheral blood after 200 mg/d thymopeptide treatment all increased significantly (P<0.05 or P<0.01). Conclusion:These results suggest that large dose of thymopeptides can increase i mmune function of patients with malignant tumor under radiotherapy,and the curat ive effect of 200 mg/d thymopeptides is better.
