The change of coronary circulating TNF-α level in patients with coronary heart disease after PTCA and its significance
- VernacularTitle:冠心病患者PTCA后冠脉循环TNF-α水平的改变及其临床意义
- Author:
Rongzeng DU
;
Zonggui WU
;
Zuo HUANG
;
Gaozhong HUANG
;
Guoyuan ZHANG
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2001;22(2):185-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of percutaneous tr ansluminal coronary angioplasty (PTCA) on coronary circulating tumor necrosis fa ctor-α (TNF-α) activity. Methods: Plasma TNF-α levls were measured with radioimmunoassay and bioactive assay respectively. Result s: Plasma TNF-α activity in femoral artery (AO) was significantly incr eased immediately after PTCA ［(15.86±3.75) U/ml vs （41.32±4.36） U/ml， P<0.01］, and plasma TNF-α activity in coronary sinus was remarkably incre ased immediately after PTCA ［(16.72±4.14） U/ml vs （65.61±6.25） U/ml, P<0.01］. There was no change in plasma TNF-α activity in AO 24 h after PT CA ［(18.32±5.12） U/ml vs （15.86±3.75） U/ml, P>0.05］. Conclu sion: The increase in plasma TNF-α activity after PTCA may be associat ed with the injury of coronary artery caused by PTCA, suggesting that TNF-α ma y be involved in the coronary occlusion and the development of coronary restenos is after PTCA.
