EXPERIMENTAL STUDY OF BONE REPAIR INDUCED BY CRYOPRESERVED ALLOGRAFT PERIOSTEUM AND FETAL BONE COMPOSITION IN BONE DEFECT
- VernacularTitle:深低温保存的同种异体骨膜与胎骨联合移植的实验研究
- Author:
Yongtao XU
;
Jiefu GU
;
Ping SHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2001;15(3):183-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the repairing effect of transplantation of allogeneic fetal bone in combination with a covering cryopreserved periosteal allograft to bone defect. Methods Twenty Long-eared white male rabbits were chosen as experimental model of bilateral 12 mm combined bony and periosteal radial defect. Cryopreserved allograft periosteum with allogeneic fetal bone were implanted in the left defect as experimental side and fetal bone was simply transplanted in the right defect as control side. Bone repair process in the two groups were compared by macroscopy, microscopy, roentgenograms and the contents of calcium and phosphate in the defect area at 2、4、8 and 12 weeks after transplantation. Results There was significant statistic difference in the contents of calcium and phosphate between the experimental and control sides at 4、8 and 12 weeks after transplantation (P<0.05). With time passing by, the contents of calcium and phosphate have the increasing trends. In the experimental group, lamella bone was seen and medullary canal recanalized at 8 weeks postoperatively. The histological section showed the bone lacuna and lamella bone were formed. Conclusion It suggests that allogeneic fetal bone in combination with a covering cryopreserved periosteal allograft can promote bone repair, and allogeneic fetal bone is excellent bone substitute.
