Dual wavelength spectrophotometry and K-ratio spectrophotometry in determining compatible stability of cefepime with metronidazole
- VernacularTitle:紫外双波长、系数倍率法测定头孢吡肟与甲硝唑配伍的稳定性
- Author:
Yufen LUO
;
Ping YE
;
Shan ZHAO
- Publication Type:Journal Article
- From:
Chinese Journal of New Drugs and Clinical Remedies
2001;20(3):194-195
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the compatible stability of cefepime with 0.5% metronidazole injection. METHODS: Dual wavelength spectrophotometry and K-ratio spectrophotometry were described for the determination of cefepime with metronidazole injection during 6 h. RESULTS: There was no evident variation in content during 6 h at room temperature. The average recovery rates of cefepime and metronidazole were (100.9±0.4)% and (99.8±0.6)% (n=5). CONCLUSION: The compatiblity of cefepime with metronidazole injection is stable. The method of using dual wavelength spectrophotometry and K-ratio spectrophotometry to determine the compatible stability of cefepime with metronidazole is simple, accurate and usable.
