Preparation and In Vitro Dissolubility of Carvedilol Solid Dispersion
- VernacularTitle:卡维地洛固体分散体的制备及其体外溶出度的测定
- Author:
Jianbin YANG
- Publication Type:Journal Article
- From:
China Pharmacy
2001;12(3):146-148
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE： To improve the dissolubility and dissolution rate of carvedilol.METHODS： Carvedilol solid dispersions were prepared using solvent－ melting and coevaporation methods with PEG－ 6000 and PVP as carriers and in vitro dissolubility was studied in simulated gastric juice.RESULTS： The results of in vitro dissolubility test showed that the higher the carrier－ car ratio,the faster the drug dissolution.The in vitro dissolubility of solid dispersions with PVP as carrier was faster than that of solid dispersions with PEG－ 6000 as carrier.CONCLUSION： Accelerating the rate of in vitro release and improving bioavailability,carvedilol solid dispersion was a promising preparation.
