Pharmacoeconomic Evaluation of Four Short- term Triple Therapeutic Schemes for Eradicating Hp
- VernacularTitle:4组短程三联方案根除幽门螺杆菌的药物经济学评价
- Author:
Huafeng CHENG
;
Huiming CAO
;
Qian CHEN
;
Nansen ZHANG
- Publication Type:Journal Article
- From:
China Pharmacy
2001;12(3):154-155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: Four different one- week triple therapeutic schemes to eradicate Helicobacter pylori were compared by pharmacoeconomic analysis to provide a scientific method for rational assignment of our limited medical fund.METHODS: According to literature reports,892 cases of duodenal ulcer and gastritis with Helicobacter pylori were selected.These patients were randomly divided into four groups which received different one- week triple therapeutic schemes: OMC(Omeprazole+ Metronidazole+ Clarithromycin),OFC(Omeprazole+ Furazolidone+ Clarithromycin),OFA(Omeprazole+ Furazolidone+ Amoxicillin)and BFC(Colloidal bismuth subcitrate+ Furazolidone+ Clarithromycin).The schemes were evaluated with pharmacoeconomic cost- effectiveness analysis.RESULTS: The cost- effectiveness ratios of OMC,OFC,OFA,BFC for gastritis or duodenal ulcer were 16.19/17.33,17.30/13.93,11.40/10.56,11.17/10.75 respectively.They changed to 16.36/17.51,17.49/14.08,8.15/7.55,11.66/11.20 by sensitivity analysis.CONCLUSION: OFA is the most effective and inexpensive one to eradicate Hp.