Alteration and clinical significance of NK cell and T lymphocyte subpopulation in patients with rectal carcinoma
- VernacularTitle:直肠癌病人外周血NK细胞和T淋巴细胞亚群数目的变化及其临床意义
- Author:
Chenglong WANG
;
Jialin TAN
- Publication Type:Journal Article
- From:
Chinese Journal of General Surgery
2001;10(3):228-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the alteration and clinical significance of NK cell and T lymphocyte subpopulatien in patients with rectal carcinoma. Methods The numbers of NK cell and T lymphocyte in 26 healthy persons and 35 rectal carcinoma patients were detected by 3H-releasing method and FCM. Results NK cell and CD3, CD4, CD4/CD8 were decreased significantly in patients with rectal carcinoma (P<0.05), which was positively correlated with Dukes staging (P<0.01), and was inereased after redical or palliative operation (P<0.05), but NK cell and CD3, CD4, CD4/CD8 were further decreased in patients with unresectable tumor after operation (P<0.05). Conclusions The immunity of rectal patients was decreased with the development of the disease, and it will be improved after radical of palliative operation.
