Clinical study of preoperative immunoguiding therapy of intratumor injection of 131I-3H11 for gastric carcinoma
- VernacularTitle:术前局部注射131I-3H11导向治疗胃癌的临床研究
- Author:
Wenbin GUO
;
Yanbo JIANG
;
Qinghua JIANG
;
Huazhu LIANG
;
Zhong GAO
- Publication Type:Journal Article
- From:
Chinese Journal of General Surgery
2001;10(3):203-205
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of intratumor injection of 131I-3H11 for gastric cancer (GC). Methods 16 patients with GC subjected to endoscopic intratumor injection of 131I-3H11 as a treatment group; 6 GC patients with FAM chemotherapy as a control group. Histological examination of the postoperative specimens of the two group were comparated. Results In treatment group, 75.0%(12/16) of cases were found to have morphological changes with karyopyknosis, karyorrhexis, coagulation of cytoplasm, and invasion of lymphocyte in mesochyma. Most of these changes were medial; but in control group no obvious morphological change was found. Conclusions The results suggest that GC subjected to endoscopic intratumor injection of 131I-3H11 preoperatively has promising application in the clinic.
