VASCULAR ENDOTHELIAL GROWTH FACTOR AND TUMOR ANGIOGENESIS
- VernacularTitle:血管内皮生长因子与肿瘤血管生成
- Author:
Yijun YANG
;
Jingsen SHI
- Publication Type:Journal Article
- From:
Chinese Journal of Bases and Clinics in General Surgery
2001;8(3):205-207
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of vascular endothelial growth factor (VEGF) on tumor angiogenesis, and its usage in tumor therapy. Methods The recent literatures about VEGF and angiogenesis were reviewed and analyzed. The advances of VEGF study were summarized. The effects of anti-angiogenesis in tumor biological therapy were introduced.Results Angiogenesis had been identified as an important factor for promoting tumor growth. VEGF was a basic and pivotal factor in tumor angiogenesis. The anti-angiogenesis treatments aimed at VEGF, including the applications of VEGF inhibitor and gene therapy of adenovirus medium, had got great progress. Conclusion VEGF is a leading factor of tumor angiogenesis, the anti-angiogenesis therapy aimed at VEGF has probably provided a new chance to malignant tumor treatment.
