Preparation and preliminary pharmacodynamic study of rectal suppository of low molecular weight heparin
- VernacularTitle:低分子肝素直肠栓剂的研制及药效学研究
- Author:
Guangxi ZHAI
;
Hengchang ZANG
;
Yuanjun ZHONG
- Publication Type:Journal Article
- From:
Chinese Journal of Biochemical Pharmaceutics
2001;22(3):119-120
- CountryChina
- Language:Chinese
-
Abstract:
Purpose The aim is to investigate the rectal suppository of low molecular weight heparin（LMWH）.Methods The suppository was prepared by way of heating and fusion，the drug release property was studied with the release test in vitro and the absorption of LMWH into blood was tested by the changes of rabbits blood coagulation time. Results The drug release property in vitro followed Fick′s diffusion equation and LMWH could enter the blood through rectal medication. Conclusion The absorption from the rectum was another route of LMWH into the blood.
