Expression of CD44 gene nm23 gene TGFα and TNFα in epithelial ovarian cancer
- VernacularTitle:卵巢癌中CD44 nm23基因及细胞因子 TGFα TNFα表达的研究
- Author:
Shulan ZHANG
;
Zhijun XIA
;
Dongni ZHAO
- Publication Type:Journal Article
- From:
Chinese Journal of Practical Gynecology and Obstetrics
2001;17(3):155-157
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the relation of the expression of intron 9 in CD44 gene,nm23 gene and the serum levels of TGFα and TNFα to the development, metastasis and prognosis of epithelial ovarian cancer. Methods The expressions of intron 9 in CD44 gene, nm23 gene, TGFα and TNFα in epithelial ovarian cancer were measured by semi -quantitative RT - PCR, immunohistochemical technique and radioimmunoassay ( RIA ). Results There was positive expression of intron 9 in CD44 gene,nm23 gene,TGFα and TNFα in 36 cases of epithelial ovarian cancer. The higher levels of nm23 gene and TGFa were obvious in early stage of ovarian cancer. ConclusionTo study the ovarian cancers biologic behavior with these multipe factors can provide theoretical basis for early diagnosis, gene therapy and predicting prognosis.
