COCHINCHINENIN—A NEW CHALCONE DIMER FROM THE CHINESE DRAGON BLOOD
- VernacularTitle:剑叶血竭素国产血竭中一个新的二聚查耳酮
- Author:
Zhihong ZHOU
;
Jinliang WANG
;
Chongren YANG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2001;36(3):200-204
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the active constituents of Dracaena cochinchinensis (Lour.) S.C.Chen. in the commercial dragon blood. METHODS Various column chromatographies with Sephadex L-20 gel, MCI gel and silica gel were employed for the isolation and purification. The structures of compounds were elucidated by spectral analysis. RESULTS Nine chalcones were isolated from the commercial dragon's blood which was made of D.cochinchinensis (Lour.) S.C.Chen.. By means of spectral data, they were identified as 1-［5-(2,4,4′-trihydroxydihydrochalconyl)］-1-(p-hydroxyphenyl)-3-(2-methoxy-4-hydroxy-phenyl)-propane (1), 2′-methoxysocotrin-5′-ol (2), socotrin-4′-ol (3), 2-methoxy-4,4′-dihydroxydihydrochalcone (4), 2,4,4′-trihydroxy-dihydrochalcone (5), 2,4,4′-trihydroxy-6-methoxydihydrochalcone (6), 2′,4′,4-trihydroxy-chalcone (7), 2-methoxy-4,4′-dihydroxychalcone (8) and 2′-methoxy-4′,4-dihydroxychalcone (9). CONCLUSION Compound 1 is a new chalcone dimer and named as cochinchinenin. Compounds 2-9 were isolated from D.cochinchinensis (Lour.) S.C.Chen. for the first time.
