BIOTRANSFORMATION OF (+)-AND (-)-CLAUSENAMIDE IN RATS
- VernacularTitle:右旋和左旋黄皮酰胺在大鼠体内代谢转化的研究
- Author:
Qingqiang YAO
;
Yan WANG
;
Muzou WANG
;
Shumin YANG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2001;36(3):224-228
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the metabolic pathway of chiral clausenamide in the rat and understand its stereoselectivity. METHODS The urine, feces and blood of rat were gathered after the drug was administered, the known metabolites were analyzed by HPLC-DAD and one unknown metabolite was elucidated by using LC-MS analysis. Metabolic stereoselectivity was determined by comparing the metabolic results of (+)- and (-)-clausenamide. RESULTS Six known metabolites were determined and one unknown metabolite was elucidated as N-demethylclausenamide. The metabolic stereoselectivity was shown distinctly. CONCLUSION Chiral clausenamide was mainly metabolized by hydroxylation in liver and the biotransformation exhibited pronounced substrate stereoselectivity.
