Significance for the expression of transforming growth factor beta in human nasal polyp and mucosa tissue
- VernacularTitle:鼻息肉中转化生长因子β亚型的表达及分布
- Author:
Qiuping WANG
;
Feng CHEN
;
Tianyou WANG
;
Xiangrong CHENG
;
Kunmin WU
- Publication Type:Journal Article
- From:
Journal of Medical Postgraduates
2001;14(3):192-195
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To explore the pathogenesis of nasal polyposis by examining the expression of transforming growth factor beta (TGF-β) in human inflammatory nasal polyps. Methods: Twenty five polyposis patients were selected, tissue TGF-β1～3 from nasal polyps and inferior turbinate mucosa were determined with immunohistochemistry APAAP method .The inferior turbinate mucosa from eight healthy volunteers were selected as control. Six polyp tissues were estimated with western-blot analyses to compare the characteristics of TGF-beta isoforms expression. Results: ①The expression of TGF-β1～3 in nasal polyps was significantly higher than that in nasal mucosa, it was undetectable in nasal mucosa from healthy volunteers;②TGF-β1 was the main isoform detected in nasal polyps. Conclusions: TGF-β, especially TGF-β1 is strongly expressed in inflammatory nasal polyps and its mucosa. TGF-β could induce modification of epithelium and connective tissue and therefore be involved in the pathogenesis of nasal polyposis.
