The vasodilative and antioxidative effects of Carvedilol——a new generation of β-receptor blockers
- VernacularTitle:卡维地洛的扩张血管和抗氧化作用
- Author:
Jihong YANG
;
Dongpei MIAO
- Publication Type:Journal Article
- From:
Journal of Medical Postgraduates
2001;14(3):265-267
- CountryChina
- Language:Chinese
-
Abstract:
Carvedilol is a novel β-receptor blocker with vasodilative and potent antioxidative effects. It may inhibit the activation of transduction factors induced by oxygen radicals, block the gene expression in cardiac remodeling, and decrease cardiomyocyte apoptosis. It is reported that carvedilol may reduce the in vivo oxidation of low density lipoprotein (LDL) and auto-antibody titre of antioxidant and increase the antioxidative capacity of LDL. Carvedilol and its metabolite BM-910228 may inhibit the inotropic response induced by oxygen radicals. Carvedilol may provide cardiac protection in acute myocardial ischemia and improve cardiac function, reduce the mortality rate of heart failure.
