The anti-inflammatory mechanisms of α-melanocyte-stimulating hormone
- VernacularTitle:α-黑色素细胞刺激素的抗炎机制
- Author:
Bo CHEN
;
Chaofeng HU
;
Huadong WANG
;
Chen LIN
;
Chujie LI
- Publication Type:Journal Article
- From:
Chinese Journal of Pathophysiology
2001;17(3):281-284
- CountryChina
- Language:Chinese
-
Abstract:
α-MSH is an endogenous neuropetide that is effective of all categories of expreimental inflammation. The mechanisms underlying the anti-inflammatory influence of α-MSH are reviewed in the article. α-MSH suppresses inflammation in the CNS and periphery by downregulating the activation of NF-κB, then inhibiting production of proinflammatory cytokines, nitric oxide, chemokines and adhension molecules, and increasing synthesis of anti-inflammatory cytokines. α-MSH is useful in the treatment of many pathological situations in humans.
