Analysis the polymorphism of apolipoprotein E gene in patients of parkinson disease with dementia
- VernacularTitle:帕金森病患者载脂蛋白E基因多态性与痴呆相关性的分析
- Author:
Fen WANG
;
Meilin LI
;
Zhijie YANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2001;5(3):50-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between PDD and the polymorphism of apolipoprotein E(apoE) gene,to inquire the etiological basis of PDD.Methods 11 Patients with PDD 40 patients with PD without dementtia and 52 unrelated controls were collected to detect the genotype of apoE gene by PCR－ RFLP. Results There was no difference in the apoE allele frequencies and genotype distribution in PDD group,PD without dementia group and control group(P >0.05). Conclusion There is no relationship between the polymorphism of apoEgene and the onset of PDD.The pathogenesis of PDD differs from that of AD.
