Experimental Study on the Effects of Immediate Administration of Inderal on Postinfarction Left Ventricular Remodeling of the Rabbit
- VernacularTitle:急性心梗后即刻给予心得安对左室重塑影响的实验研究
- Author:
Peng ZHENG
;
Zhaoming HU
- Publication Type:Journal Article
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2001;30(3):221-223
- CountryChina
- Language:Chinese
-
Abstract:
The effects of immediate administration of inderal following acute myocardial infarction on left ventricular remodeling were studied in acute myocardial infarction model of the rabbit. The results showed that there was no significant difference in the infarct size and expansion index between the infarct-inderal group and the infarct-placebo group. As compared with sham surgery-inderal group，infarct-inderal group had a higher ventricular weight，left ventricular volume index and left ventricular wall stress ［(2.65±0.17) g/kg vs (2.32±0.11) g/kg，P<0.05;(2.22±0.23) ml/kg vs (1.70±0.12) ml/kg，P<0.001;(0.84±0.07) vs (0.75±0.052)，P<0.05，respectively］，but there was no significant difference between the infarct-inderal group and infarct-placebo group. Heart rate in the infarct-inderal group was significantly decreased as compared with that of infarct-placebo group ［(153±6.36) min－1 vs (225±4.08) min－1，P<0.001］，but there was no significant difference in left ventricular end-diastolic pressure，+dp/dt max and cardiac index between the two groups. It was suggested that immediate administration of inderal postinfarction had no preventive effect on left ventricular remodeling.
