Effect of Erigeron Breviscapini on Chronic Hypoxic Pulmonary Hypertension and Serum Nitric Oxide and Endothelin-1 in Rats
- VernacularTitle:灯盏花素对大鼠低氧性肺动脉高压治疗作用及血清一氧化氮和内皮素-1的影响
- Author:
Yipeng DING
;
Yongjian XU
;
Zhenxiang ZHANG
- Publication Type:Journal Article
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2001;30(3):224-226
- CountryChina
- Language:Chinese
-
Abstract:
To study the effect of Erigeron breviscapini on chronic hypoxic pulmonary hypertension and mechanism，the hypoxic rats were injected intraperitoneally with Erigeron breviscapini. The mPAP，the content of serum nitric oxide (NO) and endothelin-1 (ET-1) were measured 5，14 and 28 days after intraperitoneal injection of Erigeron breviscapini in hypoxia respectively，and were compared with those in the single hypoxic group. The results showed that the contents of serum mPAP and ET-1 were higher，and serum NO was lower in single hypoxic group than in the normal rats (both P<0.01). The contents of serum mPAP and ET-1 were lower and NO was higher in the Erigeron breviscapini-treated group than in the single hypoxic group (P<0.01). It was suggested that Erigeron breviscapini could reduce the hypoxic pulmonary hypertension by increasing NO and decreasing ET-1 of serum. Erigeron breviscapini could be used to treat hypoxic pulmonary hypertension.
