THE EFFECT OF SIGNAL TRANSDUCTION MECHANISM ON BBB DAMAGE IN BRAIN INJURY OF RATS
- VernacularTitle:信号转导机制在大鼠脑损伤后血脑屏障损害中的作用
- Author:
Ruxiang XU
;
Liangping LI
;
Shizhen ZHONG
- Publication Type:Journal Article
- From:
Medical Journal of Chinese People's Liberation Army
2001;26(3):186-188
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to explore the mechanism of signal transduction on BBB damage in brain injury. 75 male SD rats were randomly devided into 5 groups: control, sham operation, injury only, injury with Forskolin-treatment and H7 treatment.Evans blue permeation was observed qualitatively with an epifluo resence and mesured quantitatively with a spetrophotometer.The result shcwed that Evans blue significantly permeated in injuried group,and noticeably decereased in H7 treatment group and Forskolin treatment group. It indicated that Forskolin and H7 can effectively prevent BBB opening,and suggest that Forskoling and H7 may provide new ways on BBB protection.
