The Stability of Tinidazole and Cefotaxime Sodium Mixed in Infusion Fluid
- VernacularTitle:替硝唑葡萄糖注射液与注射用头孢噻肟钠的配伍稳定性
- Author:
Chunli XU
;
Xiufang PAN
;
Zhichang ZHENG
;
Peiming WANG
;
Min ZHANG
- Publication Type:Journal Article
- From:
China Pharmacy
2001;12(4):236-237
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the stability of tinidazole and cefotaxime sodium mixed in infusion fluid at 4℃,25℃ and 37℃ for 24 hours.METHODS:Tinidazole and cefotaxime sodium were determined by RP-HPLC method and the pH of solution was determined with a pH meter.RESULTS:There were no significant changes in pH of the solution at 4℃,25℃ and 37℃ for 24 hours; Along with the duration, there were significant changes in the appearance of solution and the concentrations of tinidazole and cefotaxime sodium.UV absorption curve of tinidazole and cefotaxime mixed solution revealed small changes at 4℃ for 6 hours, 25℃ for 2 hours and 37℃ for 1 hour, showing a new peak.CONCLUSION: Tinidazole and cefotaxime sodium mixed in infusion fluid were stable at 4℃ for 6 hours,25℃ for 2 hours and 37℃ for 1 hour.
