Study on the in vitro release of tetanus toxo id from polylactide microspheres and the influence of additives on the drug release
- VernacularTitle:破伤风类毒素聚乳酸微球的体外释放研究 及附加剂对药物释放的影响
- Author:
Ying HE
;
Shuli WEI
- Publication Type:Journal Article
- From:
Journal of Peking University(Health Sciences)
2001;33(3):228-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study on in vitro release of tetanus toxoid contained in polylactide microsp heres and the influence of additives on the drug release. Methods: Some parameters affecting the rate of release were asse ssed during the in vitro experiments lasted 84 days: (1)the molecular mass of the poly mers , (2)the protein loading of the microspheres, (3)the particle sizes, (4)co-enca p sulation of additives. Results: The polylactide microspheres con taining tetanus toxoid presented considerable sustained release effect. Release kinetics of the microspheres fitted in with zero order equations. The rate of release was shown to dep end on the four parameters mentioned above. Conclusion: The poly lactide microsph eres investigated may be prospective for the development of controlled release v accines.
