Effect of the modification of ste aric acid solid lipid nanoparticles by chemical coating with Brij 78 on their body distribution in mice
- VernacularTitle:Brij 78表面修饰对硬脂酸固态脂质纳米粒体内组织分布的影响
- Author:
Dabing CHEN
;
Jie WANG
;
Qiang ZHANG
- Publication Type:Journal Article
- From:
Journal of Peking University(Health Sciences)
2001;33(3):233-237
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of s urface modification of stearic acid solid lipid nanoparticles with Brij 78 on the body distribution. Me thods: T he stearic acid solid lipid nanoparticles were prepared by “emulsi on-evaperation-solidfied at low temperature" method with two kinds of surfacta nts: Brij 78 and taurocholic acid sodium salt. Groups of five randomly selected Kun Ming mice of both sexes were used for each suspension and for each time point. After injection of each suspension into the tail vein, one group of mice were killed a t e ach time point. Then the blood, liver, spleen, lung, heart, kidney, muscles and fat were removed and the dpm value of 100 μl blood and 50 mg of each tissue was determined. Results: Compared with the nanoparticles taurocholi c acid sodium salt, the AUC (tissue)/AUC(blood) value of to spleen, lung, heart and kidney with the nanoparticles modified with Brij 78 was increased to 1 12.5%, 143.6%, 146.7% and 184.8% respectively. Conclusion: The distribution of stearic acid solid l ipid nanoparticles into the non-RES organs can be increased and the circulating time may be prolonged by modifying the nanoparticle surface with Brij 78.
