Expression Pattern of p27 Protein in Primary Gastric Lymphomas.
- Author:
Jai Hyang GO
1
Author Information
1. Department of Pathology, Dankook University College of Medicine, Cheonan, Korea. jaihyang@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Lymphoma;
Stomach;
p27 protein
- MeSH:
Lymphoid Tissue;
Lymphoma*;
Lymphoma, B-Cell;
Lymphoma, B-Cell, Marginal Zone;
Stomach
- From:Cancer Research and Treatment
2001;33(4):318-323
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the expression pattern of p27 protein in primary gastric lymphomas. MATERIALS AND METHODS: Immunostaining for the p27 protein was performed in 16 cases of low grade mucosa-associated lymphoid tissue (MALT) lymphomas and 16 cases of high grade B-cell lymphomas of the stomach. RESULTS: All low grade MALT lymphomas were positive, however all high grade lymphomas were negative forp27 protein. Most of the monocytoid cells in the low grade lymphoma were unstained. CONCLUSION: Loss of p27 protein expression is well correlated with histologic grade and appears to be associated with the high grade transformation seen in primary gastric lymphomas.
