SYNTHESIS OF SUBSTITUTED 4-STYRYLCOUMARIN AND THEIR ANTITUMOR ACTIVITIES
- VernacularTitle:取代4-苯乙烯基香豆素的合成及其抗肿瘤活性
- Author:
Song XU
;
Shiping XU
;
Lanmin LI
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2001;36(4):269-273
- CountryChina
- Language:Chinese
-
Abstract:
AIM A series of 4-styrylcoumarin derivatives had been designed and synthesized in order to find compounds of antitumor activities by screening. METHODS Title compounds (1-20) were synthesized by Phase-Transfer Wittig reaction or Wittig-Horner reaction, and screened by several antitumor models in vitro. Their structures were determined by 1HNMR, MS and elemental analysis. RESULTS Twenty compounds (1-20) are new compounds. Compound 18 had effects on KB cell lines in vitro. CONCLUSION It was seen that compound 18 had certain antitumor activities, and it was worth further studying.
