Effects of astragaloside Ⅳ on myocardiac dynamics and cardiac function with normal and depressant cardiac function in rats
- VernacularTitle:黄芪苷Ⅳ对正常和心功能受抑制大鼠左心室心肌力学的影响
- Author:
Yanxia LIU
;
Zaiping LIU
;
Jianjie JIAO
;
Jianshi LOU
- Publication Type:Journal Article
- Keywords:
Astragalus membranaceus Bge.;
astragaloside Ⅳ;
Propranolol;
myocardiac dynamics;
cardiac functions
- From:
Chinese Traditional and Herbal Drugs
2001;32(4):332-334
- CountryChina
- Language:Chinese
-
Abstract:
To study the effects of astragaloside Ⅳ, which was obtained from Astragalus membranaceus Bge., on myocardiac dynamics and cardiac function on normal and cardiac depressant rat. Methods Left ventricular pressure (LVP) and differential value of dp/dt were recorded by left ventricular catherization to observe the effect of 1 mg/kg iv astragaloside Ⅳ on normal and cardiac depressant rat induced by iv 0.75 mg/kg of Propanolol. Results Astragaloside Ⅳ decreased heart rate slightly, and showed inotropic activity by increasing dp/dtmax significantly, with improvement of cardiac diastolic function. It shortened the time constant (T) and caused no obvious change on the tension time index (TTI) in normal rat. These results suggested that astragaloside Ⅳ did not increase cardiac oxygen consumption while exerting its inotropic effect. Conclusion Astragaloside Ⅳ can improve both cardiac systolic and diastolic functions, and may be used as a candidate for the treatment of cardiac disfunction.
