Effects of sympathetic denervation on liver regeneration after partial hepatic resection
- VernacularTitle:去交感神经状态对肝部分切除后肝再生的影响
- Author:
Feng XIA
;
Zhenping HE
;
Hengchun DUAN
;
Kun LI
;
Li CHEN
;
Xiaoli WANG
;
Jiahong DONG
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
2001;23(4):416-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the animal model of denervation of sympathetic nerve and to explore the effects of denervation of the sympathetic nerve on liver regeneration after partial resection. Methods The animal model of denervation of sympathetic nerve was made with 6-OHDA. A total of thirty male Wistar rats were divided equally into experimental and control group. The left and middle lobe of liver were resected with improved Higgins and Anderson's method. Meanwhile, denervation was made in the experimental group. All the rats were killed by haemospasia on the 7 th day after operation. HMI, RLR and MI were measured. The rates of DNA synthesis were detected by 3H-TdR method. Results The concentration of NE decreased extremely on day 3 to day 14 after administration of 6-ONDA. No death happened in all the rats 7 days after liver resection. HMI, RLR, MI and 3H-TdR incorporation significantly decreased in experimental group compared with that in control (P<0.01). Conclusion The chemical denervation of sympathetic nerve can be aroused by administration of 6-OHDA. Regeneration of the liver is inhibited by the denervation of sympathetic nerves.
