Dynamic changes of pro- and anti-inflammatory cytokines in acute pancreatitis
- VernacularTitle:急性胰腺炎促炎因子和抗炎因子变化的动态观察
- Author:
Shihai XIA
;
Xiaoyan ZHAO
;
Ping GUO
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
2001;23(4):462-464
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of the dynamic changes of pro-and anti-inflammatory cytokines in the onset and development of acute panreatitis (AP). Methods Pro-inflammatory cytokines TNFα, IL-1β, IL-6, and IL-8 and anti-inflammatory cytokines IL-10 and IL-1ra in the plasma of 48 patients with AP and 20 healthy individuals were determined with ELISA. Results The levels of all pro-and anti-inflammatory cytokines in plasma was significantly higher in AP patients than in control group (P<0.05) in early stage of the disease, and then all levels were decreased gradually, consistent with the alterations of clinical symptoms of the AP patients. Conclusion The dynamic changes of pro-and anti-inflammatory cytokines might play important role in the onset and development of AP.
