The Application of Correspondence Analysis toFactorial Experiment for Analysis of Cephalosporinwith Reversed Phase High Performance Liquid chromatography
- VernacularTitle:关联度分析在反相高效液相色谱同时测定多种头孢菌素的析因试验中的应用
- Author:
Shiqian ZHU
;
Kunyi NI
;
Zhenjie WU
;
Ze LI
;
Qiguo ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Analytical Chemistry
2001;29(4):457-460
- CountryChina
- Language:Chinese
-
Abstract:
Correspondence analysis was used for determining the important factors from the six factors influencing analysis of cephalosporin in reversed phase-high performance liquid chromatography (RP-HPLC). Experiments were planed by U7（76）, then the synthetical correspondence between a series of optimizations and the factors was calculated. Result indicated that that proportion of organic solvent, pH and concentration of buffer were three most important factors. It showed that the correspondence analysis was a better method to determining the important factors in RP-HPLC
