UP-REGULATION OF EXPRESSION OF ADHESION MOLECULE ON THE SURFACE OF HUMAN VASCULAR ENDOTHELIAL CELLS BY REACTIVE CARBONYL COMPOUNDS
- VernacularTitle:活性羰基化合物对人血管内皮细胞粘附分子表达的影响
- Author:
Min LIANG
;
Fanfan HOU
;
Xun ZHANG
- Publication Type:Journal Article
- From:
Medical Journal of Chinese People's Liberation Army
2001;26(4):259-261
- CountryChina
- Language:Chinese
-
Abstract:
To elucidate the role of reactive carbonyl compounds in the pathogenesis of vascular complication in patients with chronic renal failure or diabetes. Vascular endothelial cells (VECs) were isolated from human umbilical vein and cultured with 3-deoxyglucosone (3-DG) or methylglyoxal(MGO) in vitro. Expression of ICAM-1 and VCAM-1 on the surface of VECs was detected by flow cytometer. The results showed that up-regulation of expression of ICAM-1 and VCAM-1 was observed when either 3-DG or MGO was added into the cultures, which was inhibited by a carbonyl compounds scavanger, aminoguanidine. These data suggested that accumulation of reactive carbonyl compounds in patients with chronic renal failure or diabetes might be involved in the mechanism of arteriosclerosis.
